Mathematical modelling of fibre-enhanced perfusion inside a tissue-engineering bioreactor

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Mathematical modelling of fibre-enhanced perfusion inside a tissue-engineering bioreactor.

We develop a simple mathematical model for forced flow of culture medium through a porous scaffold in a tissue-engineering bioreactor. Porous-walled hollow fibres penetrate the scaffold and act as additional sources of culture medium. The model, based on Darcy's law, is used to examine the nutrient and shear-stress distributions throughout the scaffold. We consider several configurations of fib...

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ژورنال

عنوان ژورنال: Journal of Theoretical Biology

سال: 2009

ISSN: 0022-5193

DOI: 10.1016/j.jtbi.2008.10.013